Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep127 | Calcium and Bone | ECE2021

Large parathyroid adenomas: unusual clinical characteristics

Anastasia-Konstantina Sakali , Bagias Christos , Thoda Pinelopi , Mparmpa Eleftheria , Pappa Dimitra , Georgiou Eleni , Gountios Ioannis , Tigas Stelios , Bargiota Alexandra

IntroductionThe differential diagnosis between benign and malignant parathyroid neoplasms may be challenging and should always be based on clinical and histological criteria. We are presenting a case series of three patients with clinical, biochemical and imaging findings supporting the presence of a malignant neoplasm but histological findings confirming the diagnosis of a parathyroid adenoma.Case 1A 24-year...

ea0073aep130 | Calcium and Bone | ECE2021

The benign course of MEN I disease. Implications for treatment

Athanassiou Lambros , Kostoglou-Athanassiou Ifigenia , Spyropoulos Panagiotis , Xanthakou Eleni , Mascha Olga , Fortis Athanasios , Kalogirou Thomais , Athanassiou Panagiotis

MEN (multiple endocrine neoplasia) I disease represents a compilation of multiple endocrine neoplasms affecting a patient in the course of a life-time. It thus represents a phenotype which has survived over many years. Pituitary neoplasms, lipomas and parathyroid hyperplasia are observed in the disease. The aim was to describe a patient with MEN I disease who presented with lipomas and acromegaly in his early adulthood and developed primary hyperparathyroidism in his senior ye...

ea0073aep236 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The intensity of menopausal hot flushes is associated with values of the hepatic steatosis index

Armeni Eleni , Augoulea Areti , Paschou Stavroula , Karagkouni Iliana , Mili Nikoletta , Kontou Lorena , Kaparos Georgios , Rizos Dimitrios , Panoskaltsis Theo , Lambrinoudaki Irene

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

ea0073aep494 | Pituitary and Neuroendocrinology | ECE2021

Cabergoline treatment for non functioning pituitary macroadenomas

Pappa Dimitra , Thoda Pinelopi , Anastasia – Konstantina Sakali , Barmpa Eleftheria , Georgiou Eleni , Gountios Ioannis , Alexandra Bargiota

IntroductionCabergoline seems to be a promising and effective medical treatment for the more agressive Non Functioning Pituitary Adenomas (NFPAs) by reducing or keeping tumor’s size stable long-term. Here we present the experience of our centerMethodsWe studied 7 patients with NFPAs attending our clinic the last 10 years (median period 42 months, range 12 to 114 months), in whom cabergoline was started d...

ea0073aep617 | Reproductive and Developmental Endocrinology | ECE2021

The prevalence of NAFLD in menopause: A systematic review

Ntikoudi Anastasia , Vlachou Eugenia , Evangelou Eleni , Kanakis George , Tsartsalis Athanasios N. , Vaitsi Violetta , Komninos John , Mastorakos George

IntroductionThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) varies according to age, gender and nationality. In the general population, the incidence is about 15–25%. Liver disease increases with age and its prevalence is higher in menopausal women suggesting that steroid sex hormone metabolism may play a role in the pathogenesis of NAFLD.AimThe purpose of this systematic review was to invest...

ea0073ep35 | Calcium and Bone | ECE2021

Coexistence of multiple cystic parathyroid adenomas and thyroid carcinoma

Boudina Maria , Syndouka Eleni , Fotiadou Aimilia , Stamati Mariana , Zouli Chrysanthi , Argyropoulou Elpiniki , Theodosios S. Papavramidis , Chrisoulidou Alexandra

BackgroundCystic parathyroid adenoma is a rare entity (<0.01% of all cervical masses) that leads to primary hyperparathyroidism in 9% of cases. Parathyroid scintigraphy is essential for the diagnosis although there are pitfalls with false negative results. Parathyroidectomy is the treatment of choice but its success depends on the exact preoperative localization of the parathyroid lesions. 4D-CT is a very helpful diagnostic tool in such cases.<p ...

ea0093oc43 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Statin use and perimenopausal BMI determine the risk of incident diabetes mellitus in the postmenopause: Results of Palladia study

Mavraganis George , Papanikola Nektaria , Angelopoulou Anastasia , Stefanaki Aikaterini , Armeni Eleni , Paschou Stavroula , Anelli Valentina , Augoulea Areti , Stamatelopoulos Kimon , Lambrinoudaki Irene

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...

ea0099p443 | Calcium and Bone | ECE2024

22q11.2 deletion syndrome diagnosed in the context of seizure and hypocalcemia in adulthood

Galani Maria , Effraimidis Grigoris , Gkountios Ioannis , Georgiou Eleni , Sakali Anastasia-Konstantina , Pappa Dimitra , Barmpa Eleftheria , Adamopoulos Nektarios , Bargiota Alexandra

Introduction: The 22q11.2 deletion syndrome (22q11.2DS) caused by a microdeletion of the 22q11.2 region of chromosome 22 is the most common deletion in humans causing a variety of disorders, including DiGeorge syndrome (OMIM #188400), velocardiofacial syndrome (OMIM #192430) and distal chromosome 22q11.2 deletion syndrome (OMIM #611867). Most individuals diagnosed with this condition are identified in early childhood and the diagnosis in adults is uncommon. It is characterized...

ea0099p477 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Mitochondrial diabetes and m.3243A> G mutation in MTL1 gene: MIDD/MELAS syndrome

Christou Panagiota , Christou Maria , Zisidis Christos , Siolos Athanasios , Bouba Ioanna , Bagli Eleni , Katsanos Andreas , Georgiou Ioannis , Tigas Stelios

Introduction/Aim: MIDD (maternally inherited diabetes and deafness) and MELAS (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes) are rare, maternally inherited, multisystem disorders caused by mitochondrial DNA mutations. We present the case of a patient with mitochondrial diabetes and discuss the diagnostic challenges.Case presentation: A 25-year-old female patient with a 7-year history of diabetes mellitus (DM) and suboptimal glyc...

ea0099ep255 | Calcium and Bone | ECE2024

An interesting case of co-existence of autosomal dominant hypocalcemia 1 with chronic myelogenous leukemia

Eleni Chondrogianni Maria , Kyrou Ioannis , Papadopoulou Anna , Kaperda Aikaterini , Diamantopoulos Panagiotis , Angelousi Anna , Randeva Harpal , Kassi Eva

Introduction: Autosomal dominant hypocalcemia (ADH) type 1 is a rare form of hypoparathyroidism, caused by heterozygous, inherited or de novo, activating mutations in the CASR. CASR is also expressed in the kidney and activating mutations lead to decreased calcium renal absorption. Activating mutations in the CasR, inhibits salt transport, leading to Bartteŕs syndrome (BS) type V which can co-exist with ADH1. Chronic myeloid leukemia (Cml) is characterized by the...